What is "lugdunin"

Lugdunin is an antibiotic compound, a thiazolidine-containing cyclic peptide. It was isolated in 2016 after Staphylococcus lugdunensis was identified as the species of bacteria from the human nose that suppressed growth of species of disease-causing bacteria in that part of the human microbiome.

Ludgunin is a non-ribosomally synthesized cyclic peptide that inhibits growth of Staphylococcus aureus strain. The lugdunin genes are located on a 30-kbp operon. The genes lugA, lugB, lugC, and lugD encode four non-ribosomal peptide synthases, which are preceded by a putative regulator gene lugR.

Gene

locustag

protein size/aa

Genbank protein entry

RefSeq protein entry

lugR

SLUG_RS03935

196

CCB53263.1

WP_002460032.1

lugA

SLUG_RS03940

2374

CCB53264.1

WP_002478842.1

SLUG_RS03945

124

CCB53265.1

WP_002460029.1

lugB

SLUG_RS03950

1230

CCB53266.1

WP_014533237.1

lugC

SLUG_RS03955

2937

CCB53267.1

WP_002478844.1

lugT

SLUG_RS03960

228

CCB53268.1

WP_002460022.1

lugD

SLUG_RS03965

579

CCB53269.1

WP_002478846.1