LTK may refer to the
- LTK Commune
- Leukocyte receptor tyrosine kinase, in biochemistry, a member of the receptor tyrosine kinase family of cell surface receptors
- Licence to Kill, 1989 James Bond film
- Little Kimble railway station, England; National Rail station code LTK
- Legends of the Three Kingdoms, a Chinese popular card game based on the Three Kingdoms period of China and the semi-fictional novel Romance of the Three Kingdoms (ROTK).