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LSL is a three letter acronym, which may refer to:

  • Leicestershire Senior League, a football competition
  • Leinster Senior League (association football), an amateur football league
  • Leinster Senior League (Men's hockey), a field hockey league in Ireland
  • Leinster Senior League (rugby), an Irish rugby union competition
  • Leisure Suit Larry, a series of adult adventure games
  • Linden Scripting Language, a scripting language
  • Logical shift left, a type of bitwise operation
  • Larch Shared Language, a language for algebraic specification of abstract data types
  • Lending Solutions, also known as LSL Properties, a UK-based company
  • Lincoln Savings and Loan Association, the financial institution at the heart of the Keating Five scandal
  • LSL, the ISO 4217 Code for the Lesotho loti, the currency of the Kingdom of Lesotho
  • LSL, Laurent Salvador Lamothe, former Prime Minister of Haiti, and founder of LSL World Initiative
  • Lisa Scott-Lee (born 1975), Welsh singer
  • LSL (gene), a human gene
  • Lake Shore Limited, an Amtrak railroad line
  • '' Lake Shore Limited (NYC train), the predecessor of the above line
  • Landing Ship Logistics, an amphibious warfare vessel of the United Kingdom
  • Lycée Saint-Louis, a French higher education establishment and Classe préparatoire aux grandes écoles
  • Laminated strand lumber, a type of engineered wood
  • Liberty Shoes Limited, an Indian footwear manufacturer
  • Long Service Leave, an employee vacation payable after long service in Australia and New Zealand
LSL (gene)

Leptin, serum levels of, also known as LSL, is a human gene.