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LRU can refer to:

  • Line-replaceable unit, a complex component of a vehicle that can be replaced quickly at the organizational level
  • Least Recently Used, a cache algorithm
  • Las Cruces International Airport in Las Cruces, New Mexico, USA
  • Lenoir-Rhyne University
  • Liberties and Responsibilities of Universities, French law voted in 2007
  • Latvian Russian Union, an ethnic minority, left-wing political party in Latvia