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LPE may refer to:

  • Lambda Pi Eta, a collegiate honor society
  • LAN Perú, an airline
  • Lapeer (Amtrak station), a train station
  • LimeWire Pirate Edition, file sharing software
  • Lingenfelter Performance Engineering, a car modifier
  • Liquid phase epitaxy, a semiconductor manufacturing process
  • Lone pair electrons, an atomic valence structure
  • Local privilege escalation, a type of software exploit
  • London Press Exchange, an advertising agency
  • Lysophosphatidylethanolamine, a type of organic chemical
  • Longitude of the periapsis, a dimension of orbit
  • Lepki language, of Western New Guinea