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Wiktionary
lose one's mind

vb. 1 (context idiomatic English) To become frustrated, angry. 2 (context idiomatic English) To become crazy, insane.

Usage examples of "lose one's mind".

Standing with Ben on Cardassia, he'd seen how easy it could be to lose one's mind from horror.

Music more than any other art requires so much concentration that one could easily, after creative moments, lose one's mind.