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Wiktionary
lose it

vb. 1 (context idiomatic English) To be explosively angry; to lose one's temper. 2 To begin to laugh uncontrollably. 3 To lose one's mind, go crazy. 4 To no longer have a skill or ability, to lose one's touch, to be washed up 5 (context idiomatic English) To lose control of a situation.

WordNet
lose it

v. lose control of one's emotions; "When she heard that she had not passed the exam, she lost it completely"; "When her baby died, she snapped" [syn: break down, snap]

Wikipedia
Lose It

"Lose It" is a song by Britpop band Supergrass. It was released as a single from their debut album I Should Coco. Officially, it is the third single taken from the album. However, it was a vinyl-only US release on Sub Pop Records. Only 2,500 copies were originally pressed in 1995, making it somewhat of a rarity, but it is believed more copies have been pressed in the following years. On the strength of imports, it reached #75 in the UK singles chart in 1995.

Lose It (Cartel song)

"Lose It" is a single by the five-piece American pop-rock band Cartel, recorded for the MTV show Band in a Bubble. This was the first song recorded by Cartel while they spent 20 days recording a new album in a glass bubble. It was released as the group's first single from their self-titled second album Cartel, on June 12, 2007. The song featured female vocalist Juliet Simms of the band Automatic Loveletter and the ringtone reflected her portion of the song although her vocals were removed from the video.

"Lose It" was originally written as the first track for the new album and was performed live from the bands studio on June 1, 2007 for TRL's Spankin' New Music Week. The Cartel album was released on August 21, 2007. The "Lose It" single became available on iTunes and Napster on June 12, 2007, the same day Cartel was released from the bubble.

Usage examples of "lose it".

Today's guidepost along the great road of life is use it before you lose it, my good man.

I want to be myself and enjoy what I have won, unless I lose it all.