Wikipedia
Lipoflavonoid (or Lipo-flavonoid) is a proprietary, over-the-counter, dietary supplement formula created in 1961, by NUMARK Laboratories, which is claimed by the manufacturer to improve circulation in the inner ear, as a means of combatting tinnitus (ringing in the ears). While it has not been expressly approved by the Food and Drug Administration for this purpose, the formulation and package claims comply with FDA regulations for dietary supplements.
Lipoflavonoid is currently being marketed on the Internet and in television commercials specifically to relieve tinnitus. Clinical studies of the product appearing in refereed journals address its use in treating sensorineural hearing loss, both inclusive of and exclusive of Meniere’s disease, of which tinnitus is a recognized symptom. While a Mayo Clinic article on tinnitus states there is "little evidence that alternative medicine treatments work for tinnitus," the same article goes on to specifically name Lipoflavonoid as an alternative therapy. In the early 1960s, the Audiology Center of Walter Reed Hospital conducted a double-blind, placebo-controlled study of the effects of the lemon bioflavonoid active ingredient of Lipo-flavonoid on patients with hearing loss not associated with Meniere's Disease. None of the study participants who took bioflavonoid showed improvement of hearing as measured by pure tone audiometry.