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The Collaborative International Dictionary
Lethargize

Lethargize \Leth"ar*gize\ (l[e^]th"[.a]r*j[imac]z), v. t. [imp. & p. p. Lethargized (-j[imac]zd); p. pr. & vb. n. Lethargizing (-j[imac]`z[i^]ng).] To make lethargic.

All bitters are poison, and act by stilling, and depressing, and lethargizing the irritability.
--Coleridge.

Wiktionary
lethargize

vb. To make lethargic.