LCN can refer to:
- Lincoln Central railway station, whose station code is LCN
- Library of Congress Number. Accession number for the United States library.
- London Centre for Nanotechnology, a nanotechnology research institute in London, England
- Load Classification Number, also known as the Pavement Classification Number, a measure of the bearing strength of an airport runway
- Logical channel number (also known as virtual channel in North America), channel numbers used on radio and television sets to change channel
- Logical cluster number of a volume or logical drive of a computer
- La Cosa Nostra, the Italian-American or Italian mafia in the United States
- La cosa nostra, the Sicilian mafia from which the Italian-American or Italian mafia in the United States originated.
- La Coka Nostra, a hiphop music group
- Le Canal Nouvelles, a television channel in Quebec, Canada
- Low copy number, a DNA profiling technique