In Greek mythology, the name Laonome may refer to:
- Laonome, daughter of Guneus, possible spouse of Alcaeus and mother of Amphitryon.
- Laonome, daughter of Amphitryon and Alcmene (thus granddaughter of the precedent), sister of Iphicles and half-sister of Heracles. She married an Argonaut, either Euphemus or Polyphemus.
- Laonome, mother by Hodoedocus of Kalliaros, eponym of the city Kalliaros in Locris.