What is "l-dopa"

levodopa \le`vo*do"pa\ (l[=e]`v[-o]*d[=o]"p[.a]), a. [Levo- + DOPA, dihydroxyphenylalanine.] (Chem. & Biochem.) A substance used as a therapy for Parkinson's Disease; the L form of Dopa; L-dihydroxyphenylalanine; L-hydroxytyrosine ( C9H11NO4); also called L-dopa. In the body it is converted by the enzyme dopa-decarboxylase into dopamine, the form in which it is active in the brain, affecting neural impulse transmission.

n. (alternative form of dopa English)

L-DOPA ( or levodopa ) (alt., L-3,4-dihydroxyphenylalanine) is a chemical that is made and used as part of the normal biology of humans, some animals and plants. Some animals and humans make it via biosynthesis from the amino acid L-tyrosine. L-DOPA is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline) collectively known as catecholamines. Furthermore, L-DOPA itself mediates neurotrophic factor release by the brain and CNS. L-DOPA can be manufactured and in its pure form is sold as a psychoactive drug with the INN levodopa; trade names include Sinemet, Pharmacopa, Atamet, Stalevo, Madopar, and Prolopa. As a drug, it is used in the clinical treatment of Parkinson's disease and dopamine-responsive dystonia.

L-DOPA has a counterpart with opposite chirality, D-DOPA. As is true for many molecules, the human body produces only one of these isomers (the L-DOPA form). The enantiomeric purity of L-DOPA may be analyzed by determination of the optical rotation or by chiral thin-layer chromatography ( TLC).