KSCB may refer to:
- KSCB (AM), a radio station (1270 AM) licensed to Liberal, Kansas, United States
- KSCB-FM, a radio station (107.5 FM) licensed to Liberal, Kansas, United States
- K53EG, a television station (channel 53) licensed to Sioux Falls, South Dakota, United States, also known as KSCB-TV
- Scribner State Airport (ICAO code KSCB)
KSCB (1270 AM, "Talkradio 1270am") is a radio station broadcasting a news/talk/information format. Licensed to Liberal, Kansas, USA, the station serves the Southwest Kansas area. The station is currently owned by Seward County Broadcasting Co., Inc. and features programming from Premiere Radio Networks and USA Radio Network.