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Kolumbo is an active submarine volcano in the Aegean Sea, about 8 km northeast of Cape Kolumbo, Santorini island. The largest of a line of about twenty submarine volcanic cones extending to the northeast from Santorini, it is about 3 km in diameter with a crater 1.5 km across. It was "discovered" when it breached the sea surface in 1649-50, but its explosion was not to be compared to the well-known Thera explosion and caldera collapse, currently dated ca. 1630 BCE, with its devastating consequences for Minoan civilization. The Smithsonian Institution's Global Volcanism Program treats it as part of the Santorini volcano.

The 1650 explosion, which occurred when the accumulating cone reached the surface, sent pyroclastic flows across the sea surface to the shores and slopes of Santorini, where about seventy people and many animals died. A small ring of white pumice that formed was rapidly eroded away by wave action. The volcano collapsed into its caldera, triggering a tsunami that caused damage on nearby islands up to 150 km distant. The highest parts of the crater rim are now about 10 m below sea level.

In 2006, sea floor pyroclastic deposits from the two Aegean explosions were explored, sampled and mapped by an expedition by NOAA Ocean Explorer, equipped with ROV robotics.

The crater floor, averaging about 505 m below the sea surface, is marked in its northeast area by a field of hydrothermal vents and covered by a thick bacterial community, the 2006 NOAA expedition discovered. Superheated (measured as hot as 224 °C) metal-enriched water issuing from the vents has built chimneys of polymetallic sulfide/sulfates to a maximum height of 4 m, apparently accumulated since the 1650 event.

The 2006 expedition initiated new seismic air-gun techniques in order to determine the volume and distribution of the submarine volcanic deposit of pumice and ash on the sea floor around Santorini, which has been studied extensively since 1975. Revised, more accurate estimates of the total dense rock equivalent volume of the Minoan event(s), consisting of pyroclastic sea floor deposits, distal ash fallout and ignimbrites on the island of Santorini, is likely about 60 km³, a greatly increased estimate, comparable to the largest historic explosion, Mount Tambora 1815; the increased estimate affects the size of the ensuing tsunami as it has been widely modeled.