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Wiktionary
knuckle down

vb. (context intransitive chiefly British idiomatic English) To get to work; to focus on a task.

WordNet
knuckle down

v. work very hard, like a slave [syn: slave, break one's back, buckle down]

Wikipedia
Knuckle Down

Knuckle Down is the fourteenth studio album by singer-songwriter Ani DiFranco. It is the first album that DiFranco has collaborated with a producer; Joe Henry. The record is also her first studio album to feature a string section. It is considered among her most accessible records, and compared to the stark Educated Guess, it is more abundantly produced.