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Kalay, also known as Karlay, is a town in the Sagaing Division of Myanmar. It is located upstream from Mandalay and Monywa on the Myittha River, a tributary of the Chindwin River. The town is the district headquarters of the Kalay District. It has gained importance with trans border movement enabled between Burma and India following the Tamu–Kalayamyo road built by the Border Roads Organization of India. Recently, Kalay was one of the fastest developing towns in Burma.

In July 2015, a monsoon rain triggered a natural disaster, and a state of emergency was declared in four regions of the country. The disaster caused a flash flood in Kalay and surrounding areas. Kalay was devastated by the disaster.