Wiktionary
n. (context slang English) The state of dissociation from the body commonly experienced after taking the drug ketamine.
Wikipedia
"K-hole" is a slang term for the subjective state of dissociation from the body commonly experienced after sufficiently high doses of the dissociative anesthetic ketamine. This state may mimic the experiences such as catatonic schizophrenia, out-of-body experiences (OBEs) or near-death experiences (NDEs), and is often accompanied by feelings of extreme derealization, depersonalization and disorientation, as well as temporary memory loss and vivid hallucinations.
K-HOLE is a trend forecasting group founded by Greg Fong, Sean Monahan, Chris Sherron, Emily Segal, and Dena Yago in 2010. K-hole is based in New York.