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JWH may refer to:

  • John Wesley Hardin, an American gun-fighter from the 18th century
  • John W. Henry, futures trader and owner of the Boston Red Sox
  • John Winston Howard, former Prime Minister of Australia
  • JWH-133, a medication used to prevent Alzheimer's disease
  • John W. Huffman, creator of the JWH cannabinoids
  • Jared Waerea Hargreaves- New Zealand rugby league player for the Manly Sea Eagles