justsayno Nancy Reagan's antidrug slogan, and a hint to this puzzle's theme Advice from some about pat-downs? "War on Drugs" slogan "Don't do drugs!" '80s First Lady catchphrase Antidrug mantra Slogan popularized in the 1980s ... and a hint to 17-, 25-, 28-, 48-, 51- and 60-Across Slogan popularized in the Antidrug advice Reagan-era slogan