JSK may refer to:
- Jai Shree Krishna, a salutation in Vaishnavism (in place of hello or good morning or good night), which has many meanings with the simplest being victory to Shri Krishna who is Purushottam.
- JSK Film Corporation, an Indian film production company
- JS Kabylie, an Algerian football club
- JS Kairouan, a Tunisian football club
- Jansankhya Sthirata Kosh, an Indian population concern organization
- Janette Sadik-Khan, former Commissioner of the New York City Department of Transportation