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JSC may refer to:

  • Johnson State College, one of the Vermont State Colleges, and located at Johnson, Vermont, United States
  • Joint-stock company
  • Judicial Service Commission (disambiguation), the body tasked with appointing judges in several Commonwealth countries
  • Julio Sanchez Cristo, a Latin American radio personality
  • Jubilee Sports Centre, the former name of the Hong Kong Sports Institute
  • Junior School Certificate, a public examination in Bangladesh
  • Lyndon B. Johnson Space Center, the National Air and Space Administration's mission flight control and astronaut training facility at Houston, Texas, United States
  • Vostok Aviation Company, an airline headquartered in Khabarovsk, Russia and subsidiary of UTair Group