JRB may refer to:
- ISO 639-3 code (jrb) for Judeo-Arabic language
- The Downtown Manhattan Heliport, IATA/FAA Airport code JRB or KJRB
- Janice Rogers Brown (Born 1949), United States Court of Appeals DC circuit judge, 2003-present
- Jason Robert Brown - Musical theatre composer
- John Ross Bowie, an American actor
- Vice-President Joseph Robinette Biden, Jr.
- JRB Enterprises
- Judge Roy Bean
- Juggalo Rydas Bitch, a midwestern street gang.
- James River Bridge, the James River Bridge in Newport News, Virginia.
- Jean-Robert Bellande