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JAML or Junctional Adhesion Molecule-Like, or AMICA1 is a JAM transmembrane protein family member. It is composed of two extracellular immunoglobulin-like domains, a membrane-spanning region, and a cytoplasmic tail involved in activation signaling. A known ligand of JAML is Coxsackie virus and Adenovirus Receptor ( CXADR in humans and CAR in mice) which has been shown to localize to the tight junctions of epithelial cells.

JAML-mediated activation of CAR is required for neutrophil extravasation in addition to other leukocyte/epithelial cell interaction models.

Other members of the JAM family of transmembrane proteins include JAM1, JAM2 and JAM3.