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Istrana is a comune (municipality) in the Province of Treviso in the Italian region Veneto, located about northwest of Venice and about west of Treviso. As of 31 December 2004, it had a population of 8,223 and an area of .

The municipality of Istrana contains the frazioni (subdivisions, mainly villages and hamlets) Sala, Pezzan, Ospedaletto, and Villanova.

Istrana borders the following municipalities: Morgano, Paese, Piombino Dese, Trevignano, Vedelago.