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Isfana (; ; ) is a small town located at the extreme western end of Batken Region in southern Kyrgyzstan. Isfana is situated at the southern fringe of the Fergana Valley in a region surrounded on three sides by Tajikistan.

The word "isfana" is believed to have come from the Sogdian word "asbanikat", "asbanikent" or "aspanakent" which means "the land of horses". Isfana has been inhabited since at least the 9th century. It underwent significant changes during the Soviet period. The selsoviet (rural council) of Isfana was established in 1937. The selsoviet was transformed into a village administration in 1996. In 2001, Askar Akayev issued a presidential decree to make Isfana into a town.

Isfana is the administrative center of Leilek District. The villages Myrza-Patcha, Samat, Chimgen, Taylan, Ak-Bulak, and Golbo are also governed by the Isfana Mayor's Office. According to data published on the town's official website, the population of Isfana and the subordinated villages is about 28,085. The population of Isfana itself is about 18,200.