What is "iprindole"

n. A tricyclic antidepressant.

Iprindole (Prondol, Galatur, Tertran), formerly known as pramindole, is a tricyclic antidepressant (TCA) used in Europe for the treatment of depression. It was introduced by Wyeth and has been used clinically since 1967. Notably, iprindole was the first second-generation antidepressant to be launched.

Iprindole is unique compared to most other TCAs in that it is a relatively weak inhibitor of the reuptake of serotonin and norepinephrine and instead acts predominantly as an antagonist of 5-HT receptors, hence its classification as 'second-generation'. Additionally, side effects of iprindole are much less prominent relative to other TCAs and it is well tolerated. However, iprindole's efficacy may not be as great as other TCAs, especially in regards to anxiety relief.