What is "in despite of"

Despite \De*spite"\, n. [OF. despit, F. d['e]pit, fr. L. despectus contempt, fr. despicere. See Despise, and cf. Spite, Despect.]

1. Malice; malignity; spite; malicious anger; contemptuous hate.

   With all thy despite against the land of Israel.
   --Ezek. xxv. 6.

2. An act of malice, hatred, or defiance; contemptuous defiance; a deed of contempt.

   A despite done against the Most High.
   --Milton.

   In despite, in defiance of another's power or inclination.

   In despite of, in defiance of; in spite of. See under Spite. ``Seized my hand in despite of my efforts to the contrary.''
   --W. Irving.

   In your despite, in defiance or contempt of you; in spite of you. [Obs.]