IIE can stand for:
- The Institut d'Informatique d'Entreprise, one of the French public Grandes écoles of engineering, specializing in computer science
- The Institute for International Economics, a think tank focused on international economics, based in Washington, D.C.
- The Institute of Industrial Engineers, the world's largest professional society for industrial engineering professionals, based in the United States
- The Institute of International Education, a world leader in the international exchange of people and ideas
- The Institution of Incorporated Engineers, once the UK's largest multidisciplinary engineering association, now part of IET
- The Instituto de Investigaciones Estéticas, an art history research institute at Mexico's National Autonomous University (UNAM)
- Indian Institute of Entrepreneurship
- The Apple IIe.
- The Innovative Interstellar Explorer, a proposed mission to send a probe to the heliopause.