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HWI may refer to:

  • Hauptman-Woodward Medical Research Institute, in Buffalo, New York, United States
  • Healthware International, an Italian advertising company
  • High water interval, or lunitidal interval, of tides
  • Horwich Parkway railway station, England
  • Humanity World International
  • Wismar, Germany
  • Hardware Wholesalers, Inc., now Do It Best, an American hardware retailer