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HSF may refer to:

  • " Han shot first", a phrase used when referring to a since altered scene in the first Star Wars movie
  • Hazara Student Federation, in Pakistan
  • Hawaii Superferry, a defunct American transportation company
  • Heat shock factor, a protein transcription factor
  • Heat sink and fan, components used for cooling computers
  • Heimler method of Human Social Functioning
  • Hellenic Sailing Federation, in Greece
  • Herbert Smith Freehills, an Anglo-Australian international law firm
  • High Seas Fleet, of the Imperial German Navy
  • High Sierra Format, a filesystem
  • Home Service Force, of the British Army
  • Homer Stryker Field, a stadium in Kalamazoo, Michigan, United States
  • Hornbaek Sportsforening, a Danish football club
  • Houston Shakespeare Festival, in Texas, United States
  • Human spaceflight
  • Southeastern Huastec language (retired ISO 639-3 code: hsf)