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HPO may refer to:

  • HPO formalism, an approach to temporal quantum logic
  • Highway Post Office, of the United States Postal Service
  • Homeowner Protection Office, in British Columbia, Canada
  • Hpon language, spoken in Burma
  • Human Phenotype Ontology
  • Humanist Party of Ontario, a political party in Canada
  • Hydrogen peroxide, an oxidizer
  • Premnaspirodiene oxygenase, an enzyme
  • Hippo, a protein kinase involved in the Hippo signaling pathway