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HPE may refer to:

  • Lancia Beta HPE, introduced 1975
  • Lancia Delta HPE, introduced 1995
  • Hennessey Performance Engineering
  • Hewlett Packard Enterprise
  • High Point Enterprise, a newspaper
  • High-pressure electrolysis
  • Holoprosencephaly, a cephalic disorder
  • Hope (Flintshire) railway station, in Wales
  • United Alignment of Nationalists (Greek: ), a Greek political alliance