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Hovsepian is an Armenian family name derived from Hovsep (Armenian for Joseph). Variants of Hovsepian include Hovsepyan, Ovsepyan, Osipian, Housepian, Hosepian etc. Notable people with the surname include:

  • Albert Ovsepyan, Armenian-Abkhazian politician, a member of the People's Assembly of Abkhazia and a former Vice-Speaker of the Assembly
  • Cameron Hovsepian, singer who auditioned for season 3 of the American The Voice
  • Haik Hovsepian Mehr, Iranian Christian activist and bishop of Jama'at-e Rabbani, part of the Assemblies of God in Iran until his murder in 1994
  • Jacob Petros II Hovsepian (Hagop Bedros II Hovsepian), Catholicos-Patriarch of the Armenian Catholic Church from 1749 to 1753. (See List of Armenian Catholic Patriarchs of Cilicia)
  • Karekin I Hovsepian, Catholicos of the Armenian Apostolic Church's Holy See of Cilicia in Antelias, Lebanon from 1943 to 1952. (See List of Armenian Catholicoi of Cilicia)
  • Ronald Hovsepian, businessman, President, CEO of IntraLinks Inc.
  • Sargis Hovsepyan, Armenian football player
  • Vatche Hovsepian (sometimes Housepian), Armenian musician and duduk player