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HOHMS (pronounced "Homes") is the medical acronym for "Higher-Order HistoMolecular Stratification", a term and concept which was first applied to lung cancer research and treatment theory.

The HOHMS Paradigm postulates that lung cancer cases can be more effectively treated if different tumors can be rationally classified into more homogeneous groups (or "strata"). These could then be used in randomized clinical trials with maximized potential for detecting significant differences in treatment regimens and other characteristics of the differing variants.

Rational stratification under the HOHMS paradigm uses a combination of histological criteria and molecular characteristics of the tumor.