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HMG may refer to:

  • Heavy machine gun, a class of larger-caliber weapon
  • Her Majesty's Government (term), the government of the United Kingdom
  • High-mobility group, a group of proteins
  • HMG-CoA, 3-hydroxy-3-methylglutaryl-coenzyme A
  • Holland Media Groep, now RTL Nederland
  • Human menopausal gonadotrophin, a fertility drug
  • Human Molecular Genetics, a scientific journal
  • Southwestern Guiyang Miao language, spoken in China