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HMB may refer to:

  • beta-Hydroxy beta-methylbutyric acid, a metabolite of the essential amino acid leucine, synthesized in the human body
  • Half Moon Bay, California, city in the United States
  • Hawkeye Marching Band, the marching band for the University of Iowa
  • Historical medieval battles, a modern sport
  • Humburi Senni language, spoken in Burkina Faso and Mali
  • His or Her Majesty's Bark, a ship prefix; see Her Majesty's Ship