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HLSS can refer to:

  • Half-Life Sound Selector, a program that allows users to play audio files using voice communication on games developed by Valve Corporation.
  • Heart Lake Secondary School, a high school in Brampton, Ontario, Canada
  • Hopscotch Lollipop Sunday Surprise, a 2001 album by The Frogs
  • School of Humanities, Languages and Social Sciences (UWE), Bristol