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HLF may refer to:

  • HLF (gene), Hepatic Leukemia Factor - a human gene and the protein encoded by it
  • Hapag-Lloyd Flug, a defunct German airline
  • Herbalife, an American multi-level marketing corporation
  • Heritage Lottery Fund, a British grant-giving organisation
  • Hillfoot railway station, in Scotland
  • The Higher Learning Foundation, a defunct American charity
  • Histoire littéraire de la France, a history of French literature
  • Holy Land Foundation for Relief and Development, an American Islamic charity
  • Huddersfield Literature Festival, in England
  • Hultsfred Airport, in Sweden
  • Hyderabad Literary Festival, in India
HLF (gene)

Hepatic leukemia factor is a protein that in humans is encoded by the HLF gene.