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HIO may refer to:

  • Hillsboro Airport, Washington County, Oregon, USA
  • Hypoiodous acid (HIO), an oxidising agent
  • Oslo University College (Norwegian: Høgskolen i Oslo, HiO), the largest state university college in Norway
  • Østfold University College (Norwegian: Høgskolen i Østfold, HiØ), a further and higher education institution in south-eastern Norway
  • Tsoa language, spoken in Botswana and Zimbabwe
  • Highly Inclined Orbit, a satellite orbit in a plane tilted far from the equatorial plane