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HHC may refer to:

  • Hand Held Computer, used by the US Census Bureau in 2009 for information transfer
  • Headquarters and Headquarters Company, a company-sized unit of the United States Army
  • Hereditary hemochromatosis, a genetic mutations that causes iron accumulation
  • HHC Hardenberg, a Dutch football club
  • Hill hold control, a mechanism used to assist start-up of automobiles on inclines
  • Hip Hop Congress, an organization encouraging the growth hip hop culture
  • Hip Hop Connection, a long-running hip-hop magazine
  • Hispanic Health Council, a Latino social well-being organization
  • Hungarian Helsinki Committee, a non-governmental human rights organization based in Budapest, Hungary
  • New York City Health and Hospitals Corporation, a public hospital and clinic group in New York City
  • Calcium-sensing receptor, a GPCR