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HGF may refer to:

  • Harold Grinspoon Foundation, an American Jewish youth organization
  • Helmholtz Association of German Research Centres (German: ), the largest scientific organisation in Germany
  • Hepatocyte growth factor, a paracrine cellular growth, motility and morphogenic factor
  • Hereditary gingival fibromatosis, a rare condition of gingival overgrowth
  • Human Growth Foundation, an American patients' organization
  • Mercury(IV) fluoride (HgF), HgF4, is the first mercury compound to be discovered with mercury in the oxidation state IV