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HFI may refer to:

  • Hamfest India, an amateur radio convention
  • Handball Federation of India
  • Healthy Forests Initiative, a United States federal law
  • Hereditary fructose intolerance
  • HFI Flooring Inc, a Canadian company
  • Holy Family Institute
  • Horizontal fiscal imbalance
  • Human factors integration
  • High Frequency Instrument, of the Planck spacecraft