What is "hexamethonium"

n. (context organic chemistry medicine English) Any divalent cation derived from hexamethylene diamine, but especially the hexamethyl derivative which is a ganglionic blocker

Hexamethonium is a non-depolarising ganglionic blocker, a nicotinic nACh (N) receptor antagonist that acts in autonomic ganglia by binding mostly in or on the N receptor, and not the acetylcholine binding site itself. It does not have any effect on the muscarinic acetylcholine receptors ( mAChR) located on target organs of the parasympathetic nervous system but acts as antagonist at the nicotinic acetylcholine receptors located in sympathetic and parasympathetic ganglia (N).