Hepu may refer to:People
- Hepu, an Egyptian vizier
- Hepu Commandery in China
- Hepu County (合浦县), Guangxi
- Hepu District (河浦区), former district of Shantou, Guangdong, merged to Haojiang District in 2003
- Hepu, Hubei (河铺镇), town in Luotian County
- Hepu, Zhejiang (鹤浦镇), town in Xiangshan County
Hepu was a Vizier of Ancient Egypt. He served during the reign of Tuthmosis IV.