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Henke is a surname. Notable people with the surname include:

  • Adolph Henke (1775–1843), German physician and pharmacologist known for his work in medical forensics
  • Brad William Henke (born 1966), American actor
  • Ed Henke (born 1927), former National Football League player
  • Ernst Ludwig Theodor Henke (1804–1872), German historian
  • Fritz Henke (1921–1999), World War II Waffen SS soldier awarded the Knight's Cross of the Iron Cross
  • Heinrich Philipp Konrad Henke (1752–1809), German theologian; father of Ernst Henke
  • Holger Henke (born 1960), political scientist and assistant provost at York College, City University of New York
  • Jana Henke (born 1973), German former swimmer
  • Jonathan Henke (born 1974), American political blogger
  • Karl Henke (1896–1945), World War II German general
  • Kevin Henke, American geochemist
  • Michael Henke (born 1957), German football coach and former player
  • Nolan Henke (born 1964), American golfer
  • Thaddäus Haenke (1761–1816), Bohemian geographer and explorer in South America
  • Tom Henke (born 1957), retired Major League Baseball relief pitcher
  • Wayne J. Henke (born 1941), member of the Missouri House of Representatives
  • Werner Henke (1909–1944), World War II German submarine commander
  • Ethan Henke, Fist Frat Star at the University of Iowa (2013)

Fictional characters:

  • Michelle Henke, in David Weber's Honorverse science fiction book series
  • Skezz Henke, in the HBO television drama Oz