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n. (context enzyme English) An enzyme required for DNA unwinding.


Helicases are a class of enzymes vital to all living organisms. Their main function is to unpackage an organism's genes. They are motor proteins that move directionally along a nucleic acid phosphodiester backbone, separating two annealed nucleic acid strands (i.e., DNA, RNA, or RNA-DNA hybrid) using energy derived from ATP hydrolysis. There are many helicases resulting from the great variety of processes in which strand separation must be catalyzed. Approximately 1% of eukaryotic genes code for helicases. The human genome codes for 95 non-redundant helicases: 64 RNA helicases and 31 DNA helicases. Many cellular processes, such as DNA replication, transcription, translation, recombination, DNA repair, and ribosome biogenesis involve the separation of nucleic acid strands that necessitates the use of helicases.

Usage examples of "helicase".

It seems that embedded in each gene is something called a helicase, which is part of a family of enzymes, and that this helicase, for no good reason, peels apart the two strands of chromosomes that make up your DNA, and the next thing you know you are standing at the kitchen cupboard trying to remember what the heck brought you there.