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HDF may refer to:

  • Hadfield railway station, in Derbyshire, England
  • Hereditary Disease Foundation
  • Heringsdorf Airport, near Garz on the island of Usedom, Germany
  • Hierarchical Data Format, a file format
  • High-density fiberboard
  • Hôtel-Dieu de France, a Lebanese medical center
  • Hubble Deep Field, an astronomical image
  • Human Development Foundation, in Bangkok, Thailand
  • Hungarian Defence Force
  • Hydrodefluorination