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HCB may refer to:

  • Hexachlorobenzene, a toxic fungicide formerly used as a seed treatment
  • Henri Cartier-Bresson, a French photographer considered to be the father of modern photojournalism
  • HCB (classification), a Paralympic cycling classification
  • Hampshire Cricket Board, the governing body for cricket in Hampshire, England
  • HCB South Tyrol, an ice hockey club in Italy
  • Hydrocarbonoclastic bacteria, a form of oil biodegrader
  • Hackbridge railway station, a railway station in South London
  • Hamptons Collegiate Baseball, a summer baseball organization in New York State