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Haghighi is a Persian surname. Notable people with the surname include:

  • Ali Haghighi, American biochemist
  • Ali Nobakht Haghighi (born 1948), Iranian nephrologist
  • Alireza Haghighi (born 1988), Iranian footballer
  • Mani Haghighi (born 1969), Iranian film director, screenwriter and actor
  • Mona Zandi Haghighi (born 1972), Iranian film director
  • Reza Haghighi (born 1989), Iranian footballer