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GWC may refer to:

  • Gambian Workers' Confederation, a trade union center in the Gambia
  • General Watch Co Watch Sub-Holding Company of ASUAG, now integrated into the Swatch Group
  • George Watson's College, an independent school in Edinburgh, Scotland
  • George Whitefield College, a Christian theological college in Muizenberg, Cape Town, South Africa
  • George Wythe College
  • Gnome Wave Cleaner, an audio restoration software application for Linux
  • Golden West College
  • Great West Conference, US college athletic conference
  • Great Western Chorus, a men's a cappella chorus in Bristol, England
  • Green Worker Cooperatives, a worker cooperative incubator in New York City
  • Gaming With China, a YouTube channel with 7000 subscribers